Research
Full-length RNA sequencing profiles intracellular and extracellular RNAs in euploid and aneuploid human embryos
Nature · By Takeshi Sugimoto ·
The Brief
- Researchers used full-length total RNA sequencing on human euploid and aneuploid blastocysts and their matched spent medium.
- The study profiles both intracellular and extracellular RNAs, and the abstract excerpt says the authors propose that cell-free RNA release is a process.
- The paper was published online in Nature Cell Biology on 9 November 2026 (doi:10.1038/s41556-026-02123-3).
Why it matters
The study links the chromosomal status of human embryos to the RNA they release into culture medium, which bears on how embryo quality may be studied in reproductive biology.
Who’s affected
- researchers in reproductive biology and embryology
- developmental biologists
- #embryo
- #rna sequencing
- #aneuploidy
- #cell-free rna
- #reproductive biology
Nature Cell Biology, Published online: 09 November 2026; doi:10.1038/s41556-026-02123-3 Sugimoto, Mariya et al. use full-length total RNA sequencing on human euploid and aneuploid blastocysts and their matched spent medium. They propose that cell-free RNA release is a process…
Timeline
Published online in Nature Cell Biology
nature.com
Full-length RNA sequencing profiles intracellular and extracellular RNAs in euploid and aneuploid human embryos