Research
Frequency of pharmacogenomic variation and medication exposures among participants in the All of Us Research Program
Science · By Andrew Haddad, Aparna Radhakrishnan, Sean McGee, Joshua D. Smith, Jason H. Karnes, Eric Venner, Marsha M. Wheeler, Karynne Patterson, Kimberly Walker, Divya Kalra, Sara E. Kalla, Qiaoyan Wang, Kathleen Polkowski, Richard A. Gibbs, Gail P. Jarvik, Janeth Sanchez, Anjene Musick, Andrea H. Ramirez, Joshua C. Denny, Philip E. Empey, Brian Ahmedani, Habib Ahsan, Hoda Anton-Culver, Maria Argos, Dave W. Arnold, Brisa Aschebook-Kilfoy, Katie Baca-Motes, Catherine Balthazar, Laura Bartlett, Gillian Bartlett-Esquilant, Melissa Basford, Leland Baskin, Mark Begale, Eric Boerwinkle, Ingrid Bonilla-Mercado, Alexander Borowsky, Amaryllis Silva Boschetti, Matthew Breeden, Brad Bryan, Jessica Burke, Elizabeth Burnside, Lisa Cadmus-Bertram, Librada Callender, Roberta Carlin, Olveen Carrasquillo, Suchitra Chandrasekaran, Alexander Charney, Mine Cicek, Cheryl Clark, Elizabeth Cohn, Vivian Colon-Lopez, Alejandro Comellas, Karl Cooper, Linda Cottler, Errol Crook, Elizabeth Culler, Martha Daviglus, Kathy Deerinwater, Liliana Lombardi Desa, Jacob Ditsch, Kim Doheny, Charles Drum, Milton Eder, Mark Edmunds, Evan Eichler, Leslie Eiland, Kim Enard, Rachel Everhart, Adolph Falcon, Dorothy Farrar-Edwards, Becky Fein, Zeno Frano, Yuri Fresko, Gretchen Funk, Stacey Gabriel, Marie Gantz, Michael Garrett, Ali G. Gharavi, Richard Gibbs, David Glazer, Marc Goodman, Philip Greenland, Allen Greiner, Richard Grucza, Lourdes Guerrios-Rivera, Aditi Gupta, Sandra Halverson, Eileen Handberg, Paul Harris, Scott Joseph Hebbring, Robert Hiatt, Joyce Ho, William R. Hogan, Beverly Wilson Holmes, Laura Horne, George Hripcsak, Priscilla Igho-Pemu, Rosario Isasi, Jessica Isom, Neeta Jain, Praduman Jain, Jessica Jarmin, Gail Jarvik, Christine D. Cole Johnson, Megan Jula, Royan Kamyar, Elizabeth W. Karlson, Rainu Kaushal, Amber Brown Keebler, Robert Kelley, Kathleen Keogh, Vik Kheterpal, Sue Kim, Frida Kleiman, Isaac Kohane, Bruce Korf, Monica Kraft, Babbette Lamarca, Linda Perez Laras, Brendan Lee, Niall Lennon, Dessie Levy, Beth Lewis, Elizabeth Cora Lewis, Megan Lewis, David Ming-Hung Lin, Christopher Lough, Mitchell Lunn, David Klein, Todd Mahr, Emily Makahi, Ted Malmstrom, Oscar Marroquin, Judith Martin, Vivienne Marshall, Elizabeth Mayer-Davis, Jacob McCauley, Brinkoetter April McCrea, Patrick McGovern, Jeffrey McKinney, David McPherson, Daniella Meeker, Robert Meller, Jose Melo, Michael Minor, Irma Molina, Janitza Montalvo-Ortiz, Julia Moore-Vogel, Francisco A. Moreno, Shawn N. Murphy, Dianne Debra Murray, Evan Muse, Paul Nemeskal, George T. O’Connor, Juno Obedin-Maliver, Lucila Ohno-Machado, Akinlolu Ojo, Tammy Ojo, May Okihiro, Matt Pagel, Kapil Parakh, Elizabeth Parks, Cathryn Peltz-Rauchman, Jill Peltzer, Tim Peterson, Anthony Philippakis, Fornessa Randal, Subhara Raveendran, Heidi Rehm, Gail Reilly, Jody Reilly, Eric Reiman, Steven Reis, Heather Reisinger, Anne-Marie Rick, Edgar M. Gil Rico, Nelida Rivera, Tonya Roberson, Dan Roden, Laura Rosales, Margaret Elizabeth Ross, Tracie Rosser, Mercedita Roxas-Murray, Bruce Sachais, Matthias Salathe, Linda Salgin, Sherilyn Sawyer, Jeffrey Scherrer, Eric Schlueter, A. Mark Schmidt, Nicole Seagriff, Elizabeth Shenkman, William Simonson, Amy Sitapati, Sanjay Skukla, Debra Smith, Jordan Smoller, Cynthia So-Armah, Bento Marcelo Soares, Arambula Teshia G. Solomon, Kimberly Sprenger, Louisa Stark, Gene Stegeman, Scott Sutherland, Christin Suver, Michael Taitel, Gregory Talavera, Amy Taylor, Kyla Taylor, Ronnie Tepp, Andreas A. Theodorou, Steve Thibodeau, Cheryl Thomas, Jeffrey Thompson, Daniel Hernandez Tinoco, Eric Topol, Scott Topper, Rhonda Trousdale, Phil Tsao, Bryce Turner, Jen Uhrig, Celina Valencia, Jason Vassy, Shyam Visweswaran, Miriam Vos, Russ Waitman, Jamie Walz, Preston Watkins, Chia-Lin Wei, Jones Deborah Weiss, Scott T. Weiss, Jeffrey Whittle, Blaker Wilkerson, Consuelo Wilkins, Steve Wimmer, Eboni Winford, Katrina Yamazaki, Fady Youssef, Alicia Zhou & Stephan Zuchner ·
The Brief
- The study reports the frequency of pharmacogenomic variation among participants in the All of Us Research Program.
- The study also reports medication exposures among these participants.
- It was published in Science Translational Medicine, Volume 18, Issue 875, in November 2026.
Why it matters
Knowing how common pharmacogenomic variants are in a large, diverse cohort, alongside actual medication use, helps researchers judge how often gene-drug interactions could affect prescribing.
Who’s affected
- pharmacogenomics researchers
- clinicians and pharmacists interested in precision medicine
- researchers using All of Us data
- #pharmacogenomics
- #precision-medicine
- #medication-exposure
- #all-of-us
- #genomics
Science Translational Medicine, Volume 18, Issue 875 , November 2026.
Timeline
Study published in Science Translational Medicine (Volume 18, Issue 875)
science.org
Frequency of pharmacogenomic variation and medication exposures among participants in the All of Us Research Program