Research
Evolutionarily reinforced GC-rich motif enables non-AUG translation in mammals under eIF1/5MP-mediated fidelity control
Science · By Haruyuki Furukawa, Abhineet Banerjee, Antonin Tidu, Nirmala Bardiya, Susumu Ishiguro, Chingakham Ranjit Singh, Hitomi Yagi, Hiroyuki Hiraishi, Grant Brooke, Antoine Perret, Kinsley Ochsner, Hailey Casey, Grace Sakai, Megan Freeman, Anastasia Meyer, Keat Robinson, William Finnane, Payton Henderson, Takeru Kameda, Yuichi Togashi, Toshinobu Fujiwara, Franck Martin, Hiroaki Kato, Kazuyuki Takai & Katsura Asano ·
The Brief
- A study in Science Advances reports that an evolutionarily reinforced GC-rich motif enables non-AUG translation in mammals.
- The mechanism is described as operating under eIF1/5MP-mediated fidelity control.
- The work was published in Science Advances, Volume 12, Issue 46, November 2026.
Why it matters
It describes a mechanism by which mammalian translation can start at non-AUG codons, which bears on how readers understand gene expression and start-codon selection.
Who’s affected
- molecular biologists
- researchers studying translation initiation and gene expression
- #translation
- #non-aug start codon
- #gene expression
- #eif1
- #mammals
Science Advances, Volume 12, Issue 46 , November 2026.
Timeline
Study published in Science Advances (Volume 12, Issue 46)
science.org
Evolutionarily reinforced GC-rich motif enables non-AUG translation in mammals under eIF1/5MP-mediated fidelity control