Research
Enhancer-driven gene regulatory network of human forebrain development provides insights into autism
Nature · By Alexandre Jourdon ·
The Brief
- A paper in Nature Communications, published online 14 November 2026, constructs a gene regulatory network of human forebrain development.
- The authors report a potential role for specific enhancer elements in driving lineage imbalance in autism.
Why it matters
It proposes a regulatory mechanism that could help explain how autism-related changes arise during early forebrain development, which may guide future genetic and organoid-based research.
Who’s affected
- researchers in neurodevelopment and autism genetics
- scientists using human forebrain organoid models
- #autism
- #neurodevelopment
- #gene regulation
- #enhancers
- #forebrain organoids
Nature Communications, Published online: 14 November 2026; doi:10.1038/s41467-026-79602-6 The authors construct a gene regulatory network showing the potential role of specific enhancer elements in driving lineage imbalance in autism, explaining why forebrain organoids from…
Timeline
Paper published online in Nature Communications
nature.com
Enhancer-driven gene regulatory network of human forebrain development provides insights into autism