Research
Dual inhibition of TNF-α and IL-1β signaling through BIG2 ameliorates osteoarthritis in mouse and primate models
Science · By Wenyu Fu, Ronghan Liu, Jin Wo, Xin Liu, Shuya Wang, Wenhao Song, Haoran Zhu, Yazhou Cui, Yuehong Chen, Chao Wang, Lei Zhang, Ran Schwarzkopf, Irvin Oh, Daniel H. Wiznia, Guodong Sun & Chuan-ju Liu ·
The Brief
- A study in Science Translational Medicine reports that dual inhibition of TNF-α and IL-1β signaling through BIG2 ameliorates osteoarthritis.
- The findings come from mouse and primate models.
- The paper appears in Volume 18, Issue 875 of the journal, November 2026.
Why it matters
The study suggests that targeting BIG2 could block two inflammatory signals, TNF-α and IL-1β, that drive osteoarthritis, but the evidence so far comes from animal models only.
Who’s affected
- researchers in osteoarthritis and joint disease
- drug developers working on inflammatory signaling pathways
- #osteoarthritis
- #inflammation
- #tnf-alpha
- #il-1beta
- #big2
Science Translational Medicine, Volume 18, Issue 875 , November 2026.
Timeline
Study reported by Science Translational Medicine
science.org
Dual inhibition of TNF-α and IL-1β signaling through BIG2 ameliorates osteoarthritis in mouse and primate models