Research
Cryo-EM reveals conserved baseplate-architecture and distinct accessory-protein assemblies in mycobacteriophages Claus, Corndog and Mysterious
Nature · By Sunil Kumar Tewary ·
The Brief
- Cryo-EM structures at atomic resolution were reported for three mycobacteriophages: Claus, Corndog and Mysterious.
- The three phages share a conserved baseplate core.
- Each phage decorates that core with different accessory proteins, which helps explain how related siphophages build distinct baseplates.
Why it matters
The work shows how closely related mycobacteriophages can share a conserved baseplate core while differing in accessory proteins, which is useful background for researchers studying phage structure and host infection.
Who’s affected
- researchers studying bacteriophage structural biology
- microbiologists working on mycobacteria
- #cryo-em
- #bacteriophage
- #mycobacteriophage
- #baseplate
- #structural biology
Nature Communications, Published online: 10 November 2026; doi:10.1038/s41467-026-79213-1 Atomic-resolution structures of three mycobacteriophages reveal a conserved baseplate core decorated by diverse accessory proteins, showing how related siphophages build distinct baseplate…
Timeline
Published online in Nature Communications (doi:10.1038/s41467-026-79213-1)
nature.com
Cryo-EM reveals conserved baseplate-architecture and distinct accessory-protein assemblies in mycobacteriophages Claus, Corndog and Mysterious