Research
Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval
eLife · By Bradley C Lega ·
The Brief
- Researchers gave human participants scopolamine, a muscarinic cholinergic antagonist, to study how cholinergic signalling relates to memory.
- The study reports a role for human hippocampal theta activity in memory encoding but not in retrieval.
Why it matters
Cholinergic dysfunction is a hallmark of Alzheimer's disease and other memory disorders, but the neurophysiological mechanisms linking it to memory have been poorly understood. This work points to hippocampal theta activity as one mechanism involved in encoding.
Who’s affected
- neuroscientists studying memory and hippocampal oscillations
- researchers working on Alzheimer's disease and other memory disorders
- #hippocampus
- #theta oscillations
- #cholinergic signaling
- #memory encoding
- #scopolamine
- #alzheimer's disease
Cholinergic dysfunction is a hallmark of Alzheimer’s disease and other memory disorders. Yet, the neurophysiological mechanisms linking cholinergic signaling to memory remain poorly understood. In this study, we administered scopolamine, a muscarinic cholinergic antagonist, to…
Timeline
Study listed as a latest eLife article
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Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval