Research
Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling
Nature · By Rana Dilara Incebacak Eltemur ·
The Brief
- The study reports that TBP fragments activate calpains in neurons.
- The activated calpains disrupt AMOT-YAP1 signalling.
- The pathway is involved in normal neural development and is implicated in spinocerebellar ataxia type 17.
Why it matters
The findings link TBP cleavage by calpains to disruption of AMOT-YAP1 signalling, a possible mechanism in spinocerebellar ataxia type 17 that science readers working on neurodegeneration or neural development may want to follow.
Who’s affected
- neuroscientists studying neurodegeneration
- researchers studying spinocerebellar ataxia type 17
- developmental biologists studying neural development
- #neuroscience
- #calpain
- #yap1
- #spinocerebellar ataxia 17
- #neural development
Nature Communications, Published online: 09 November 2026; doi:10.1038/s41467-026-79055-x TBP fragments activate calpains and disrupt AMOT-YAP1 signalling, revealing a pathway involved in normal neural development and implicated in spinocerebellar ataxia type 17.
Timeline
Study published online in Nature Communications
nature.com
Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling