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Blocking excess scarring helps prevent heart failure development

Medical Xpress ·

Blocking excess scarring helps prevent heart failure development

The Brief

  • Researchers prevented severe heart failure in a mouse model of heart attack by blocking a protein linked to excess scar tissue.
  • Excess scar tissue in the heart contributes largely to most heart failure cases, and currently has no treatments.
  • The findings come from a mouse model; the source reports no human trial results.

Why it matters

It points to a possible new therapeutic target for heart failure, a condition that currently lacks treatments aimed at excess cardiac scarring, though the evidence so far is from mice.

Who’s affected

  • cardiologists and heart failure researchers
  • patients at risk of heart failure after heart attack

Most heart failure cases are caused to a large degree by a buildup of excess scar tissue in the heart, which currently has no treatments. Now, researchers have successfully prevented the development of severe heart failure in a mouse model of heart attack by blocking a protein…

Timeline

  1. Medical Xpress reports the mouse study preventing severe heart failure by blocking a scarring-related protein

  2. Medical Xpress - latest medical and health news stories

    Blocking excess scarring helps prevent heart failure development

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    Blocking excess scarring helps prevent heart failure development – The Morning Science