Research
Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc
Current Biology · By Jana F. Fuhrmann, Vincenzo Maria Schimmenti, Greta Cwikla, Sangwon Lee, Mariana Barrera Velazquez, Michaela Yuan, Michaela Wilsch-Bräuninger, Frank Jülicher, Marko Popović & Natalie A. Dye ·
The Brief
- Fuhrmann, Schimmenti and colleagues quantified fold morphology on 3D apical surfaces of the Drosophila wing disc epithelium.
- Using ultrastructure analysis, physical modeling and genetic perturbation, they report that folds adhere apically to the apical extracellular matrix.
- The study links this apical adhesion to how folds form during wing disc morphogenesis.
Why it matters
The work shows that the apical extracellular matrix can shape epithelial folding in a developing tissue, which matters for researchers studying how tissues acquire their three-dimensional form.
Who’s affected
- developmental biologists
- researchers studying epithelial morphogenesis and extracellular matrix
- #drosophila
- #wing disc
- #morphogenesis
- #extracellular matrix
- #epithelium
Fuhrmann, Schimmenti, et al. quantify fold morphology on 3D apical surfaces of the Drosophila wing disc epithelium. Using ultrastructure analysis, physical modeling, and genetic perturbation, they show that folds adhere apically to apical extracellular matrix. This adhesion…
Timeline
Article published by cell.com
cell.com
Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc