Research
Adipogenic MSC-derived COL-3 drives M2-like macrophage polarization via PI3K-AKT to alleviate sepsis-induced lung injury
Nature ·
The Brief
- A study reports that COL-3 derived from adipogenic mesenchymal stem cells drives M2-like macrophage polarization.
- The reported mechanism involves the PI3K-AKT pathway.
- The study reports that this process alleviates sepsis-induced lung injury.
Why it matters
It identifies a candidate mechanism, macrophage polarization via PI3K-AKT, by which stem-cell-derived COL-3 may limit lung damage in sepsis, which can guide future mechanistic and therapeutic research.
Who’s affected
- researchers in sepsis, lung injury and macrophage biology
- #sepsis
- #macrophages
- #mesenchymal stem cells
- #lung injury
- #pi3k-akt