Research
A trapped catalytic product acts as molecular glue for innate immune signalosome assembly
Science · By Qi Liu, Zhongjian Bai, Tianyi Liu, Fangshuai Jia, Yi Ji, Canxi Chen, Yao Gong, Liuyuan Duan, Jiahui Zhou, Qian Guo, Ling Zhu, Huarui Kang, Haiyong Wang, Zhewen Shen, Xiaoxiang Huang, Jiayi Shen, Wenguang Shao, Junbiao Chang, Jijie Chai, Yixiao Zhang, Zhifu Han, Chenlu Zhang & Zehan Hu ·
The Brief
- A Science paper reports that a trapped catalytic product acts as a molecular glue for innate immune signalosome assembly.
- The article is listed in Science, Volume 394, Issue 6825, November 2026.
- The source provides only the title and bibliographic details, so the mechanism and experimental findings are not described here.
Why it matters
The finding describes how a small molecule produced by an enzyme may promote assembly of innate immune signalling complexes, which could inform how immune signalling is understood and studied.
Who’s affected
- researchers studying innate immune signalling
- immunologists and structural biologists
- #innate immunity
- #molecular glue
- #signalosome
- #immune signalling
- #catalysis
Science, Volume 394, Issue 6825 , November 2026.
Timeline
Article published in Science (Volume 394, Issue 6825)
science.org
A trapped catalytic product acts as molecular glue for innate immune signalosome assembly