Research
A lysosomal DRAM1-GLUT1-NADPH axis coordinates glucose sensing with metabolic reprogramming
Molecular Cell · By Jia Li, Jaclyn S. Long, Alejandro Huerta Uribe, Annabel Minton, Jing Hui Neo, Paula Fernández-Palanca, Engy Shokry, Jim O’Prey, David McEwan, David Sumpton & Kevin M. Ryan ·
The Brief
- Li et al. report a lysosome-based feedback system that helps cells adapt to excess glucose.
- High glucose increases DRAM1 and NADPH, which promotes retention of the glucose transporter GLUT1 at lysosomes.
- With GLUT1 held at lysosomes, glucose entry and glycolysis fall, and cells shift toward greater reliance on glutamine.
Why it matters
The work describes a mechanism linking glucose sensing at lysosomes to metabolic reprogramming, which could inform research on how cells regulate glucose uptake and fuel use.
Who’s affected
- cell biologists and metabolism researchers
- #metabolism
- #lysosome
- #glucose
- #glut1
- #glutamine
- #glycolysis
Li et al. identify a lysosome-based feedback system that helps cells adapt to excess glucose. High glucose increases DRAM1 and NADPH, promoting GLUT1 retention at lysosomes, reducing glucose entry and glycolysis, and shifting cells toward greater reliance on glutamine to fuel…
Timeline
Study published in Molecular Cell
cell.com
A lysosomal DRAM1-GLUT1-NADPH axis coordinates glucose sensing with metabolic reprogramming