Research
A lactate-fatty acid loop drives prostate cancer bone colonization by mediating metabolic interplay between tumor cells and osteoblasts
Nature · By Renuka Dahiya ·
The Brief
- Bone metastases in advanced prostate cancer are difficult to treat and are associated with poor outcomes.
- The authors report that bone-colonizing prostate tumor cells exploit lactate, according to the article's abstract, which is truncated in the source.
- The study is published in Nature Communications with doi 10.1038/s41467-026-79651-x.
Why it matters
It points to metabolic interplay between prostate tumor cells and bone-forming osteoblasts as a possible target for treating bone metastases, which currently have poor outcomes.
Who’s affected
- prostate cancer researchers
- oncologists treating advanced prostate cancer
- bone metastasis researchers
- #prostate cancer
- #bone metastasis
- #lactate
- #tumor metabolism
- #osteoblasts
Nature Communications, Published online: 10 November 2026; doi:10.1038/s41467-026-79651-x Bone metastases in advanced prostate cancer remain difficult to treat and are associated with poor outcomes. Here, the authors show that bone-colonizing prostate tumor cells exploit lactate…
Timeline
Published online in Nature Communications
nature.com
A lactate-fatty acid loop drives prostate cancer bone colonization by mediating metabolic interplay between tumor cells and osteoblasts