Research
A consensus spinal cord cell-type atlas across mouse, macaque, and human
Neuron · By Matthew T. Schmitz, Nelson J. Johansen, Niklas Kempynck, Inkar Kapen, Yuanyuan Fu, Madeleine Hewitt, Stephanie C. Seeman, Emily Kussick, Olivia Gautier, Michael J. Leone, Song-Lin Ding, Yuan Gao, Ashwin Bhandiwad, Jeanelle Ariza, Angela Ayala, Stuard Barta, Jacob A. Blum, Liliana Cano-Gomez, Trangthanh Cardenas, Anish Bhaswanth Chakka, Nasmil Valera Cuevas, Nicholas Donadio, Katherine A. Fancher, Emma D. Thomas, Rebecca Ferrer, Jeff Goldy, Samantha D. Hastings, Daniel Hirschstein, Windy Ho, Cindy Huang, Zoe C. Juneau, Sa Rang Kim, Zachary R. Lewis, Elizabeth Liang, Naomi X. Martin, Josh Nagra, Dakota Newman, Myung-Chul Noh, Paul Olsen, Alana Oyama, Nick Pena, Helen Poldsam, Patrick L. Ray, Melissa Reding, Christine Rimorin, Augustin Ruiz, Nadiya V. Shapovalova, Lyudmila Shulga, Cassandra Sobieski, Amy Torkelson, Morgan Wirthlin, Shenqin Yao, Helen C. Lai, Andreas Pfenning, Allan-Hermann Pool, Rebecca Seal, Bosiljka Tasic, Jonathan T. Ting, Jack Waters, Zizhen Yao, Aaron D. Gitler, Stein Aerts, Delissa McMillen, Lydia Ng, Hongkui Zeng, Cindy T.J. van Velthoven, Tanya L. Daigle, Kimberly A. Smith, Rebecca D. Hodge, Ed S. Lein & Trygve E. Bakken ·
The Brief
- Researchers Schmitz, Johansen and colleagues built a consensus cell-type atlas of the mammalian spinal cord.
- The atlas integrates gene expression, chromatin accessibility and spatial data across human, macaque and mouse.
- Cell identity and laminar position are broadly conserved across the three species, while the dorsal horn differs between them.
Why it matters
The atlas gives neuroscientists a common reference for comparing spinal cord cell types across mouse, macaque and human, which can help judge how far mouse studies of spinal circuits transfer to humans.
Who’s affected
- neuroscientists studying spinal cord circuits
- researchers using mouse models for pain and sensory research
- anyone working on spinal cord injury or motor control
- #spinal cord
- #cell atlas
- #single-cell genomics
- #neuroscience
- #cross-species comparison
Schmitz, Johansen, et al. build a consensus cell type atlas of the mammalian spinal cord, integrating gene expression, chromatin accessibility, and spatial data across human, macaque, and mouse. Cell identity and laminar position are broadly conserved, while the dorsal horn…
Timeline
Study published in Neuron (cell.com)
cell.com
A consensus spinal cord cell-type atlas across mouse, macaque, and human