# Vagus-Hepatic-Creatine axis modulates manic-like behaviors via hippocampal MMP19 upregulation in bipolar disorder

Source: [nature.com](https://www.nature.com/articles/s41380-026-03938-0) · 2026-11-13 · Mind
Page: https://themorning.science/story/vagus-hepatic-creatine-axis-modulates-manic-like-behaviors-via-hippocampal-mmp19-a76b73f6608b31ac
Kind: research · Impact: low

## In brief

- A research article titled 'Vagus-Hepatic-Creatine axis modulates manic-like behaviors via hippocampal MMP19 upregulation in bipolar disorder' was published online in Molecular Psychiatry on 13 November 2026.
- The title reports that a vagus-hepatic-creatine axis modulates manic-like behaviours in a bipolar disorder model.
- The title links this axis to hippocampal upregulation of MMP19.

## Why it matters

The study proposes a body-to-brain pathway linking the liver, creatine metabolism and the vagus nerve to manic-like behaviour, which could point to new research targets for bipolar disorder. Only the title and publication metadata were available, so the strength of the evidence and any translation to patients are unknown.

## Timeline

- 2026-11-13: Published online in Molecular Psychiatry

## Coverage

- [Vagus-Hepatic-Creatine axis modulates manic-like behaviors via hippocampal MMP19 upregulation in bipolar disorder](https://www.nature.com/articles/s41380-026-03938-0) — nature.com, 2026-11-13

Tags: bipolar-disorder, mania, vagus-nerve, creatine, mmp19

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science