# Upfront PCI Still Not Beneficial for Stable CAD as Far Out as 25 Years

Source: [MedPageToday.com - medical news for physicians](https://www.medpagetoday.com/meetingcoverage/aha/123844) · 2026-11-11 · Medicine
Page: https://themorning.science/story/upfront-pci-still-not-beneficial-for-stable-cad-as-far-out-as-25-years-62552f2a179d72ee
Kind: research · Impact: medium

## In brief

- Extended follow-up of the COURAGE and ISCHEMIA trials over up to 25 years found no improvement in hard clinical outcomes with upfront PCI versus conservative management in stable coronary artery disease.
- The result was reported from the AHA meeting coverage on MedPage Today dated 2026-11-11.
- The study concerns patients with stable CAD treated with an invasive strategy compared with conservative management.

## Why it matters

Long-term evidence that routine upfront PCI does not reduce hard outcomes in stable CAD supports continued use of conservative medical management as a valid first strategy for these patients.

## Versions

- COURAGE
- ISCHEMIA

## Timeline

- 2026-11-11: Extended 25-year results of COURAGE and ISCHEMIA trials reported at AHA meeting

## Coverage

- [Upfront PCI Still Not Beneficial for Stable CAD as Far Out as 25 Years](https://www.medpagetoday.com/meetingcoverage/aha/123844) — MedPageToday.com - medical news for physicians, 2026-11-11

Tags: cardiology, coronary artery disease, percutaneous coronary intervention, clinical trials, long-term outcomes

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science