# Tumor-colonizing Bifidobacterium dentium promotes tumor progression and chemotherapy resistance via MMP3 and GABA-FOXA2-P-gp axis

Source: [cell.com](https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00559-8?rss=yes) · 2026-11-09 · Medicine
Page: https://themorning.science/story/tumor-colonizing-bifidobacterium-dentium-promotes-tumor-progression-and-chemothe-8efedad951ac4601
Kind: research · Impact: medium

## In brief

- Pan et al. report that Bifidobacterium dentium colonizing tumours promotes tumour progression and resistance to chemotherapy.
- The study links B. dentium to induction of MMP3.
- The authors describe a GABA-FOXA2-P-gp axis through which the bacterium promotes P-gp upregulation.

## Why it matters

It suggests that microbes inside tumours can influence how cancers respond to chemotherapy, pointing to host-microbe interactions as a possible factor in treatment resistance.

## Timeline

- 2026-11-09: Study published in Cell Reports Medicine

## Coverage

- [Tumor-colonizing Bifidobacterium dentium promotes tumor progression and chemotherapy resistance via MMP3 and GABA-FOXA2-P-gp axis](https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00559-8?rss=yes) — cell.com, 2026-11-09

Tags: microbiome, chemotherapy resistance, tumour microenvironment, bifidobacterium, cancer biology

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science