# TRIM47 drives cardiac ischemia/reperfusion injury by impairing mitochondrial function and fatty acid metabolism in male mice

Source: [nature.com](https://www.nature.com/articles/s41467-026-79182-5) · 2026-11-14 · Life
Page: https://themorning.science/story/trim47-drives-cardiac-ischemia-reperfusion-injury-by-impairing-mitochondrial-fun-4a0acbca7fcb3e80
Kind: research · Impact: low

## In brief

- The study reports that TRIM47 drives cardiac ischaemia/reperfusion injury in male mice.
- According to the source, TRIM47 impairs mitochondrial function and fatty acid metabolism.
- The authors report that TRIM47 facilitates ubiquitination-dependent nuclear translocation of FOXO1.

## Why it matters

Cardiac ischaemia/reperfusion injury is described as a prevalent and hard-to-treat clinical complication, and the study points to the TRIM47–FOXO1 pathway as a possible target, though the findings so far are reported only in male mice.

## Timeline

- 2026-11-14: Published online in Nature Communications

## Coverage

- [TRIM47 drives cardiac ischemia/reperfusion injury by impairing mitochondrial function and fatty acid metabolism in male mice](https://www.nature.com/articles/s41467-026-79182-5) — nature.com, 2026-11-14

Tags: cardiology, ischaemia-reperfusion, mitochondria, fatty-acid-metabolism, foxo1, mouse-model

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science