# Topographical mismatch sustains open microchannels in living soft tissue for non-destructive protein biopsy

Source: [nature.com](https://www.nature.com/articles/s41467-026-78755-8) · 2026-11-11 · Life
Page: https://themorning.science/story/topographical-mismatch-sustains-open-microchannels-in-living-soft-tissue-for-non-ab5c9d1923278bdf
Kind: research · Impact: medium

## In brief

- Researchers report a multi-lobed microneedle device that keeps micron-scale conduits open in living soft tissue.
- According to the source, the conduits stay open for seven days.
- The device is described as allowing repeated protein sampling without destructive tissue removal.

## Why it matters

Skin-attached devices often become inflamed or collapse, which limits repeated sampling. A device that keeps tissue conduits open could make repeated, non-destructive protein biopsies practical for longitudinal studies.

## Timeline

- 2026-11-11: Published online in Nature Communications

## Coverage

- [Topographical mismatch sustains open microchannels in living soft tissue for non-destructive protein biopsy](https://www.nature.com/articles/s41467-026-78755-8) — nature.com, 2026-11-11

Tags: microneedles, biopsy, wearable sensors, soft tissue, protein sampling, biomedical devices

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science