# TMEM45A promote triple-negative breast cancer (TNBC) related depression via the AKT/mTOR signaling pathway

Source: [Biological sciences : nature.com subject feeds](https://www.nature.com/articles/s41598-026-77981-w) · 2026-11-09 · Life
Page: https://themorning.science/story/tmem45a-promote-triple-negative-breast-cancer-tnbc-related-depression-via-the-ak-3198b659a7bed5b7
Kind: research · Impact: low

## In brief

- A study reports that TMEM45A promotes depression related to triple-negative breast cancer (TNBC).
- The study links this effect to the AKT/mTOR signaling pathway.
- The source is a Scientific Reports article listed on nature.com; no summary was provided.

## Why it matters

It identifies a possible molecular pathway behind depression in TNBC patients, which could inform future research on targets for treating it. The findings are preliminary and the source provides no further detail.

## Timeline

- 2026-11-09: Research article listed on nature.com subject feed

## Coverage

- [TMEM45A promote triple-negative breast cancer (TNBC) related depression via the AKT/mTOR signaling pathway](https://www.nature.com/articles/s41598-026-77981-w) — Biological sciences : nature.com subject feeds, 2026-11-09

Tags: breast cancer, triple-negative breast cancer, depression, tmem45a, akt/mtor signaling

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science