# TMEM192 is a calcineurin-regulated membrane receptor for ubiquitin-independent lysophagy

Source: [nature.com](https://www.nature.com/articles/s41556-026-02135-z) · 2026-11-12 · Life
Page: https://themorning.science/story/tmem192-is-a-calcineurin-regulated-membrane-receptor-for-ubiquitin-independent-l-6c4428c7354abcac
Kind: research · Impact: medium

## In brief

- Liu et al. report that TMEM192 acts as a ubiquitin-independent lysophagy receptor.
- Lysosomal calcium activates calcineurin, which dephosphorylates TMEM192 to expose an LC3-binding site.
- The study was published online in Nature Cell Biology on 12 November 2026.

## Why it matters

It describes a route for clearing damaged lysosomes that does not require ubiquitin tagging, which matters for researchers studying lysosomal quality control and autophagy.

## Timeline

- 2026-11-12: Published online in Nature Cell Biology

## Coverage

- [TMEM192 is a calcineurin-regulated membrane receptor for ubiquitin-independent lysophagy](https://www.nature.com/articles/s41556-026-02135-z) — nature.com, 2026-11-12

Tags: lysophagy, autophagy, lysosome, calcineurin, membrane receptor

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science