# The optogenetic tool ASAP acutely inhibits autophagy

Source: [nature.com](https://www.nature.com/articles/s41556-026-02124-2) · 2026-11-12 · Life
Page: https://themorning.science/story/the-optogenetic-tool-asap-acutely-inhibits-autophagy-c1345357e674df89
Kind: research · Impact: medium

## In brief

- Mondal et al. present ASAP, an optogenetic tool designed to rapidly inhibit autophagy.
- Proteomic profiling with ASAP identifies the most tightly regulated autophagy substrates, including nuclear pore components.
- The work was published online in Nature Cell Biology on 12 November 2026.

## Why it matters

ASAP gives researchers light-controlled, acute inhibition of autophagy, allowing them to separate direct autophagy targets from downstream effects of longer-term inhibition.

## Timeline

- 2026-11-12: Published online in Nature Cell Biology

## Coverage

- [The optogenetic tool ASAP acutely inhibits autophagy](https://www.nature.com/articles/s41556-026-02124-2) — nature.com, 2026-11-12

Tags: autophagy, optogenetics, proteomics, cell biology

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