# The Cdh23tm2a mouse allele causes progressive hearing loss that is not improved by postnatal Cdh23 gene expression

Source: [Biological sciences : nature.com subject feeds](https://www.nature.com/articles/s41598-026-78429-x) · 2026-11-15 · Life
Page: https://themorning.science/story/the-cdh23tm2a-mouse-allele-causes-progressive-hearing-loss-that-is-not-improved-84433dd50cbfbd50
Kind: research · Impact: medium

## In brief

- A mouse allele called Cdh23tm2a causes progressive hearing loss.
- Restoring Cdh23 gene expression after birth does not improve this hearing loss.
- The source provides only the headline and feed listing, with no summary, so further details are unknown.

## Why it matters

The result suggests that postnatal Cdh23 expression alone may not reverse hearing loss caused by this allele, which matters for researchers using this mouse model or studying gene-based approaches to hearing loss.

## Versions

- Cdh23tm2a

## Coverage

- [The Cdh23tm2a mouse allele causes progressive hearing loss that is not improved by postnatal Cdh23 gene expression](https://www.nature.com/articles/s41598-026-78429-x) — Biological sciences : nature.com subject feeds, 2026-11-15

Tags: hearing loss, cdh23, mouse model, gene expression, genetics

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science