# The CD39/CD73 adenosinergic pathway is increased by proinflammatory states and modified by chemo-radiation in human non-small cell lung cancer

Source: [cell.com](https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00556-2?rss=yes) · 2026-11-09 · Medicine
Page: https://themorning.science/story/the-cd39-cd73-adenosinergic-pathway-is-increased-by-proinflammatory-states-and-m-1258e2062526dd38
Kind: research · Impact: medium

## In brief

- Researchers report that the adenosine-producing enzymes CD39 and CD73 are expressed locally in more than 85% of non-small cell lung cancers.
- The pathway is described as inducible and driven by proinflammatory states, and it is immunosuppressive.
- Expression is preferentially higher in lung adenocarcinomas with elevated tumour-infiltrating lymphocytes (TILs) and PD-L1, and chemo-radiation modifies the pathway.

## Why it matters

The study links an inflammation-driven, immunosuppressive adenosine pathway to lung tumours and shows that chemo-radiation alters it, which bears on how tumour immunity is understood in this cancer.

## Timeline

- 2026-11-09: Study published in Cell Reports Medicine

## Coverage

- [The CD39/CD73 adenosinergic pathway is increased by proinflammatory states and modified by chemo-radiation in human non-small cell lung cancer](https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00556-2?rss=yes) — cell.com, 2026-11-09

Tags: lung cancer, adenosine, cd39, cd73, tumor immunology, chemoradiation

---

Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science