# TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins

Source: [nature.com](https://www.nature.com/articles/s41594-026-01908-2) · 2026-11-11 · Life
Page: https://themorning.science/story/tf-maps-fast-high-resolution-functional-and-allosteric-mapping-of-dna-binding-pr-1aee78e607edf938
Kind: research · Impact: medium

## In brief

- TF-MAPS is a scalable platform for charting functional maps of sequence-specific DNA-binding proteins.
- The study, by Li and Lehner, was published online in Nature Structural & Molecular Biology on 11 November 2026.
- The authors use TF-MAPS to map allostery in three transcription factors.

## Why it matters

It offers a faster, higher-resolution way to map how DNA-binding proteins function and how allosteric effects propagate through them, which can inform studies of gene regulation.

## Timeline

- 2026-11-11: Published online in Nature Structural & Molecular Biology

## Coverage

- [TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins](https://www.nature.com/articles/s41594-026-01908-2) — nature.com, 2026-11-11

Tags: transcription factors, allostery, dna-binding proteins, protein function, structural biology

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science