# Tachykinin-like NLP-58 signaling through TKR-1 modulates thermotaxis behavior in Caenorhabditis elegans

Source: [PLOS Genetics](https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1012346) · 2026-11-11 · Life
Page: https://themorning.science/story/tachykinin-like-nlp-58-signaling-through-tkr-1-modulates-thermotaxis-behavior-in-4e162be55d2e7298
Kind: research · Impact: low

## In brief

- A PLOS Genetics paper reports that tachykinin-like neuropeptide NLP-58 signalling through its receptor TKR-1 modulates thermotaxis behaviour in the nematode Caenorhabditis elegans.
- The study is framed by the central role of neurokinin B signalling in mammalian thermoregulatory dysfunction.
- The paper's authors include Moon Sun Jang, Hironori J. Matsuyama and Ikue Mori.

## Why it matters

The work identifies a specific neuropeptide pathway that shapes how C. elegans moves in response to temperature, offering a simple genetic model for studying neuropeptide control of thermosensory behaviour.

## Timeline

- 2026-11-11: Published in PLOS Genetics

## Coverage

- [Tachykinin-like NLP-58 signaling through TKR-1 modulates thermotaxis behavior in Caenorhabditis elegans](https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1012346) — PLOS Genetics, 2026-11-11

Tags: c. elegans, thermotaxis, neuropeptides, tachykinin, thermosensation

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science