# STAT3 controls IL-6–induced epigenomic remodeling and restrains a latent STAT1-associated interferon program in human macrophages

Source: [science.org](https://www.science.org/doi/abs/10.1126/sciadv.aek8053?af=R) · 2026-11-11 · Life
Page: https://themorning.science/story/stat3-controls-il-6-induced-epigenomic-remodeling-and-restrains-a-latent-stat1-a-cfb28ce073848e38
Kind: research · Impact: low

## In brief

- A Science Advances study reports that STAT3 controls IL-6-induced epigenomic remodelling in human macrophages.
- The authors report that STAT3 also restrains a latent STAT1-associated interferon program in these cells.

## Why it matters

It clarifies how IL-6 signalling reshapes gene regulation in human macrophages, which is relevant to understanding inflammatory and interferon-related immune responses.

## Timeline

- 2026-11-11: Study published in Science Advances (Volume 12, Issue 46)

## Coverage

- [STAT3 controls IL-6–induced epigenomic remodeling and restrains a latent STAT1-associated interferon program in human macrophages](https://www.science.org/doi/abs/10.1126/sciadv.aek8053?af=R) — science.org, 2026-11-11

Tags: stat3, il-6, macrophages, epigenomics, interferon

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science