# Sperm phospholipase C signaling via PLCζ1 and PLCδ4 is essential for Ca 2+ oscillations and fertility in mice

Source: [PLOS Biology](https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004098) · 2026-11-06 · Life
Page: https://themorning.science/story/sperm-phospholipase-c-signaling-via-plc-1-and-plc-4-is-essential-for-ca-2-oscill-dc1f7d82aa3f6903

by Neha Gupta, Lei Zhang, Hiroki Akizawa, Maria G. Gervasi, Darya A. Tourzani, Pablo E. Visconti, Ana Romarowski, Mariano Buffone, Wei Cui, Rafael A. Fissore Fertilization-induced calcium (Ca 2+ ) oscillations are essential for egg activation and embryonic development in mammals…

## Coverage

- [Sperm phospholipase C signaling via PLCζ1 and PLCδ4 is essential for Ca 2+ oscillations and fertility in mice](https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004098) — PLOS Biology, 2026-11-06

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