# Senescent T cells within the tumor microenvironment are a potent driver for tumor growth, stemness, and chemotherapy resistance

Source: [cell.com](https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00558-6?rss=yes) · 2026-11-06 · Medicine
Page: https://themorning.science/story/senescent-t-cells-within-the-tumor-microenvironment-are-a-potent-driver-for-tumo-0fc0255684c41ab7

Zhang et al. identify that senescent T (Tsen) cells accumulate within tumors and drive tumor growth, metastasis, stemness, and chemotherapy resistance. Mechanistically, lipid-enriched Tsen SASPs reprogram tumor lipid metabolism and activate STAT1/STAT3 signaling. Targeting Tsen…

## Coverage

- [Senescent T cells within the tumor microenvironment are a potent driver for tumor growth, stemness, and chemotherapy resistance](https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00558-6?rss=yes) — cell.com, 2026-11-06

---

Brief generated by AI (–) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science