# Rewiring dendritic cell function with CLEC9A and DEC205 CARs

Source: [nature.com](https://www.nature.com/articles/s41590-026-02711-3) · 2026-11-13 · Medicine
Page: https://themorning.science/story/rewiring-dendritic-cell-function-with-clec9a-and-dec205-cars-493599f83fec96fa
Kind: research · Impact: medium

## In brief

- Published online in Nature Immunology on 13 November 2026 (doi:10.1038/s41590-026-02711-3).
- The authors engineer chimeric antigen receptor dendritic cells (CAR-DCs) with CLEC9A and DEC205 CARs to alter specific dendritic cell functions.
- The available excerpt is truncated, so the specific intracellular design and experimental results are not included here.

## Why it matters

It shows that T-cell-style chimeric antigen receptor engineering can be applied to dendritic cells to tune their functions, which is relevant to cell-based immunotherapy research.

## Timeline

- 2026-11-13: Published online in Nature Immunology

## Coverage

- [Rewiring dendritic cell function with CLEC9A and DEC205 CARs](https://www.nature.com/articles/s41590-026-02711-3) — nature.com, 2026-11-13

Tags: dendritic cells, chimeric antigen receptor, cell engineering, immunotherapy, immunology

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science