# Regression to the mean in before-after studies of digestive enzyme replacement in very preterm infants

Source: [Medical research : nature.com subject feeds](https://www.nature.com/articles/s41430-026-01850-y) · 2026-11-11 · Medicine
Page: https://themorning.science/story/regression-to-the-mean-in-before-after-studies-of-digestive-enzyme-replacement-i-2c3b6009cb9de7e3
Kind: research · Impact: low

## In brief

- A nature.com article titled "Regression to the mean in before-after studies of digestive enzyme replacement in very preterm infants" appeared in a subject feed dated 2026-11-11.
- The source provided contains no summary, so the study's methods, sample and findings are not available here.
- The headline indicates the article examines whether regression to the mean can distort before-after studies of digestive enzyme replacement in very preterm infants.

## Why it matters

Before-after studies without a comparison group can attribute natural fluctuations or regression to the mean to a treatment, so readers assessing enzyme replacement evidence in very preterm infants should check how such effects were handled.

## Coverage

- [Regression to the mean in before-after studies of digestive enzyme replacement in very preterm infants](https://www.nature.com/articles/s41430-026-01850-y) — Medical research : nature.com subject feeds, 2026-11-11

Tags: neonatology, preterm infants, enzyme replacement, regression to the mean, study design

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science