# Reconstructing developmental and disease progression with sample-level embeddings

Source: [cell.com](https://www.cell.com/cell/fulltext/S0092-8674(26)01268-7?rss=yes) · 2026-11-09 · Life
Page: https://themorning.science/story/reconstructing-developmental-and-disease-progression-with-sample-level-embedding-55c110d82701d46a
Kind: research · Impact: medium

## In brief

- An scRNA-seq framework embeds each sample by the density distribution of its cells across cellular states.
- The framework is applied to infection, neurodegeneration, embryonic development, and whole-organism perturbation.
- It aims to resolve continuous variation that discrete sample labels obscure.

## Why it matters

Sample-level embeddings based on cell-state distributions offer a way to analyse gradual biological change, such as disease progression, that simple categorical labels miss.

## Timeline

- 2026-11-09: Article published in Cell

## Coverage

- [Reconstructing developmental and disease progression with sample-level embeddings](https://www.cell.com/cell/fulltext/S0092-8674(26)01268-7?rss=yes) — cell.com, 2026-11-09

Tags: scrna-seq, single-cell, embeddings, developmental-biology, neurodegeneration, infection

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science