# PKA signaling controls ILC3 homeostasis and IL-23-mediated inflammation in the gut

Source: [nature.com](https://www.nature.com/articles/s41590-026-02703-3) · 2026-11-11 · Medicine
Page: https://themorning.science/story/pka-signaling-controls-ilc3-homeostasis-and-il-23-mediated-inflammation-in-the-g-be8a8b1069d9a5eb
Kind: research · Impact: medium

## In brief

- Prostaglandin engages protein kinase A (PKA) in ILC3 cells, according to the Nature Immunology study by Sonnenberg and colleagues.
- Sustained PKA activation promotes the depletion of ILC3s.
- IL-23 can drive aberrant PKA signaling, which is linked to gut inflammation.

## Why it matters

The study identifies a signalling pathway that controls ILC3 cell numbers and IL-23-driven inflammation in the gut, which may inform future work on intestinal inflammatory disease.

## Timeline

- 2026-11-11: Published online in Nature Immunology

## Coverage

- [PKA signaling controls ILC3 homeostasis and IL-23-mediated inflammation in the gut](https://www.nature.com/articles/s41590-026-02703-3) — nature.com, 2026-11-11

Tags: ilc3, pka signalling, gut inflammation, il-23, prostaglandin, immunology

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science