# Perioperative Therapy Tops Prostatectomy Alone in High-Risk Prostate Cancer

Source: [MedPageToday.com - medical news for physicians](https://www.medpagetoday.com/meetingcoverage/esmovideopearlsprostateca/123852) · 2026-11-12 · Medicine
Page: https://themorning.science/story/perioperative-therapy-tops-prostatectomy-alone-in-high-risk-prostate-cancer-e752ef1894807500
Kind: research · Impact: medium

## In brief

- A substudy of the phase III PROTEUS trial, presented at the ESMO congress, tested adding apalutamide and androgen-deprivation therapy before and after radical prostatectomy in high-risk localized prostate cancer.
- The perioperative regimen was compared with prostatectomy alone, and MedPage Today reported that it outperformed surgery alone.
- The findings were published as a letter in the New England Journal of Medicine, Volume 395, Issue 19, pages 1965-1968.

## Why it matters

It offers trial evidence on whether combining a hormone-targeting drug with surgery around the operation may improve outcomes for men with high-risk localized prostate cancer, a question that bears directly on treatment decisions.

## Timeline

- 2026-11-12: Results published in the New England Journal of Medicine (Volume 395, Issue 19)

## Coverage

- [Perioperative Therapy Tops Prostatectomy Alone in High-Risk Prostate Cancer](https://www.medpagetoday.com/meetingcoverage/esmovideopearlsprostateca/123852) — MedPageToday.com - medical news for physicians, 2026-11-12
- [Perioperative Apalutamide in High-Risk Localized Prostate Cancer](https://www.nejm.org/doi/full/10.1056/NEJMc2611613?af=R&rss=currentIssue) — nejm.org, 2026-11-11

Tags: prostate cancer, apalutamide, clinical trial, radical prostatectomy, androgen deprivation therapy

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science