# PARP1 hyperactivation uncouples transcription from protein expression through nuclear RNA retention

Source: [cell.com](https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00720-3?rss=yes) · 2026-11-06 · Life
Page: https://themorning.science/story/parp1-hyperactivation-uncouples-transcription-from-protein-expression-through-nu-851b8db3f7cc5063

Ortega et al. show that PARP1 hyperactivation suppresses translation by promoting nuclear RNA retention. APE1-dependent cleavage of abasic sites triggers PARP1 hyperactivation, increasing nuclear PAR, which competes with RNA for binding to RNA-binding proteins. This disrupts RNA…

## Coverage

- [PARP1 hyperactivation uncouples transcription from protein expression through nuclear RNA retention](https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00720-3?rss=yes) — cell.com, 2026-11-06

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