# OsCPK17- and OsMPK6-mediated dual phosphorylation of OsPUB12 maintains OsPUB2-regulated OsPUB12 homeostasis and balances rice immunity

Source: [nature.com](https://www.nature.com/articles/s41467-026-79063-x) · 2026-11-11 · Life
Page: https://themorning.science/story/oscpk17-and-osmpk6-mediated-dual-phosphorylation-of-ospub12-maintains-ospub2-reg-d7728e3e1e5f8abe
Kind: research · Impact: low

## In brief

- Study in Nature Communications (published 11 November 2026) reports that OsCPK17 and OsMPK6 phosphorylate OsPUB12 at two sites.
- OsPUB2 degrades OsPUB12 to promote rice immunity, according to the source summary.
- Phosphorylation of OsPUB12 by OsCPK17 and OsMPK6 is reported to fine-tune its stability and the plant's defense response.

## Why it matters

The work describes a molecular mechanism that balances stability of an immune regulator in rice, which may inform efforts to understand and engineer crop disease resistance.

## Timeline

- 2026-11-11: Study published online in Nature Communications

## Coverage

- [OsCPK17- and OsMPK6-mediated dual phosphorylation of OsPUB12 maintains OsPUB2-regulated OsPUB12 homeostasis and balances rice immunity](https://www.nature.com/articles/s41467-026-79063-x) — nature.com, 2026-11-11

Tags: rice, plant immunity, phosphorylation, protein degradation, crop disease resistance

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science