# Nudix protein D250R promotes African swine fever virus infection by disrupting host ubiquitination machinery

Source: [nature.com](https://www.nature.com/articles/s41467-026-79340-9) · 2026-11-11 · Life
Page: https://themorning.science/story/nudix-protein-d250r-promotes-african-swine-fever-virus-infection-by-disrupting-h-3debf5221e24751e
Kind: research · Impact: medium

## In brief

- A Nature Communications study reports that the African swine fever virus protein D250R promotes infection.
- The study describes an immune-evasion mechanism in which the virus targets ubiquitin activation.
- According to the abstract, loss of D250R attenuates the virus, which identifies D250R as a key virulence factor.

## Why it matters

The findings identify a specific viral protein and host ubiquitination pathway involved in African swine fever virus infection, which may inform future antiviral or vaccine research.

## Timeline

- 2026-11-11: Study published online in Nature Communications

## Coverage

- [Nudix protein D250R promotes African swine fever virus infection by disrupting host ubiquitination machinery](https://www.nature.com/articles/s41467-026-79340-9) — nature.com, 2026-11-11

Tags: african swine fever, virology, ubiquitination, immune evasion, nudix protein

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science