# Nucleotide excision repair deficiency identified by mutational signatures is associated with cisplatin response in triple-negative breast cancer

Source: [Biological sciences : nature.com subject feeds](https://www.nature.com/articles/s41523-026-01080-2) · 2026-11-12 · Life
Page: https://themorning.science/story/nucleotide-excision-repair-deficiency-identified-by-mutational-signatures-is-ass-87c7e5e24f768fd7
Kind: research · Impact: medium

## In brief

- A study links nucleotide excision repair deficiency, identified through mutational signatures, to cisplatin response in triple-negative breast cancer.
- The reported association concerns how these tumours respond to cisplatin treatment.

## Why it matters

Mutational signatures that reveal repair deficiency could help identify which triple-negative breast cancer patients are more likely to respond to cisplatin, which may inform treatment selection.

## Timeline

- 2026-11-12: Study reported in nature.com subject feed

## Coverage

- [Nucleotide excision repair deficiency identified by mutational signatures is associated with cisplatin response in triple-negative breast cancer](https://www.nature.com/articles/s41523-026-01080-2) — Biological sciences : nature.com subject feeds, 2026-11-12

Tags: breast cancer, cisplatin, dna repair, mutational signatures, precision oncology

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science