# KAS-CUT&Tag for direct mapping of transcription bubbles

Source: [nature.com](https://www.nature.com/articles/s41594-026-01917-1) · 2026-11-13 · Life
Page: https://themorning.science/story/kas-cut-tag-for-direct-mapping-of-transcription-bubbles-7902d8ac67c5ac3d
Kind: research · Impact: medium

## In brief

- KAS-CUT&Tag is a new method that maps transcription bubbles, the transiently unwound DNA regions during transcription, directly.
- Current methods track DNA unwinding during transcription only indirectly, according to the source.
- The method is reported in Nature Structural & Molecular Biology by Wu et al., published online 13 November 2026.

## Why it matters

Direct mapping of transcription bubbles gives researchers a more direct view of an early step in gene transcription than indirect methods provide.

## Timeline

- 2026-11-13: Study published online in Nature Structural & Molecular Biology

## Coverage

- [KAS-CUT&Tag for direct mapping of transcription bubbles](https://www.nature.com/articles/s41594-026-01917-1) — nature.com, 2026-11-13

Tags: transcription, chromatin, genomics, dna-unwinding, cut-and-tag

---

Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science