# Inverse correlation between a putative surrogate marker reflecting aldehyde oxidase activity and urinary hypoxanthine/xanthine ratio in Xdh knockout mice

Source: [Biological sciences : nature.com subject feeds](https://www.nature.com/articles/s41598-026-79081-1) · 2026-11-10 · Life
Page: https://themorning.science/story/inverse-correlation-between-a-putative-surrogate-marker-reflecting-aldehyde-oxid-c168f727401bc136
Kind: research · Impact: low

## In brief

- A Scientific Reports article reports an inverse correlation between a putative surrogate marker of aldehyde oxidase activity and the urinary hypoxanthine/xanthine ratio in Xdh knockout mice.
- The study was listed in nature.com's biological sciences subject feed on 2026-11-10.
- The marker is described as putative, so its validity as a surrogate has not been established by the source material provided.

## Why it matters

It suggests a urinary measure might serve as a proxy for aldehyde oxidase activity in a mouse model, which could matter to researchers studying purine metabolism and related enzymes.

## Timeline

- 2026-11-10: Study listed in nature.com biological sciences subject feed

## Coverage

- [Inverse correlation between a putative surrogate marker reflecting aldehyde oxidase activity and urinary hypoxanthine/xanthine ratio in Xdh knockout mice](https://www.nature.com/articles/s41598-026-79081-1) — Biological sciences : nature.com subject feeds, 2026-11-10

Tags: aldehyde oxidase, xanthine dehydrogenase, purine metabolism, urinary biomarkers, knockout mice

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science