# In situ profiling of plasma cell clonality with image-based single-cell transcriptomics

Source: [nature.com](https://www.nature.com/articles/s41592-026-03296-3) · 2026-11-10 · Life
Page: https://themorning.science/story/in-situ-profiling-of-plasma-cell-clonality-with-image-based-single-cell-transcri-395f3f161317df00
Kind: research · Impact: medium

## In brief

- BCR-MERFISH is an image-based method for in situ profiling of plasma cell clonality.
- It combines V gene-specific detection with spatial transcriptomics to track plasma cell clones.
- The paper was published online in Nature Methods on 10 November 2026.

## Why it matters

It offers a way to link clonal identity of plasma cells, based on V gene detection, with gene expression in intact tissue at single-cell resolution.

## Timeline

- 2026-11-10: Published online in Nature Methods (doi:10.1038/s41592-026-03296-3)

## Coverage

- [In situ profiling of plasma cell clonality with image-based single-cell transcriptomics](https://www.nature.com/articles/s41592-026-03296-3) — nature.com, 2026-11-10

Tags: spatial transcriptomics, plasma cells, b cell receptor, clonality, single-cell

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science