# In situ CAR engineering and nanoparticle-mediated TREM2 degradation for macrophage reprogramming in malignant ascites

Source: [nature.com](https://www.nature.com/articles/s41563-026-02769-2) · 2026-11-06 · Physics
Page: https://themorning.science/story/in-situ-car-engineering-and-nanoparticle-mediated-trem2-degradation-for-macropha-256cc393077cb439

Nature Materials, Published online: 06 November 2026; doi:10.1038/s41563-026-02769-2 Targeted lipid nanoparticles reprogram TREM2+-tumour-associated macrophages in ascitic fluid into chimeric antigen receptor macrophage cells, providing an in situ cell engineering strategy that…

## Coverage

- [In situ CAR engineering and nanoparticle-mediated TREM2 degradation for macrophage reprogramming in malignant ascites](https://www.nature.com/articles/s41563-026-02769-2) — nature.com, 2026-11-06

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