# Human antibody combinations determined by epitope mapping of orthopoxvirus A33/A35 confer therapeutic protection in mice

Source: [science.org](https://www.science.org/doi/abs/10.1126/scitranslmed.aeb2836?af=R) · 2026-11-11 · Medicine
Page: https://themorning.science/story/human-antibody-combinations-determined-by-epitope-mapping-of-orthopoxvirus-a33-a-ad9988d09bd20701
Kind: research · Impact: medium

## In brief

- Researchers mapped the epitopes of the orthopoxvirus A33 and A35 proteins that human antibodies target.
- Certain human antibody combinations based on this epitope mapping conferred therapeutic protection in mice.
- The study was published in Science Translational Medicine, Volume 18, Issue 875, November 2026.

## Why it matters

The results show that specific combinations of human antibodies against defined orthopoxvirus targets can protect animals after infection in a mouse model, which informs how antibody-based treatments for orthopoxvirus infections might be designed.

## Timeline

- 2026-11-11: Study published on science.org in Science Translational Medicine

## Coverage

- [Human antibody combinations determined by epitope mapping of orthopoxvirus A33/A35 confer therapeutic protection in mice](https://www.science.org/doi/abs/10.1126/scitranslmed.aeb2836?af=R) — science.org, 2026-11-11

Tags: orthopoxvirus, antibodies, epitope mapping, therapeutics, mouse models

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science