# Glial progenitor-like state is preferentially co-opted in glioblastoma and sustained by POU3F3

Source: [cell.com](https://www.cell.com/neuron/fulltext/S0896-6273(26)00808-1?rss=yes) · 2026-11-11 · Mind
Page: https://themorning.science/story/glial-progenitor-like-state-is-preferentially-co-opted-in-glioblastoma-and-susta-a96c9d5fe12ca381
Kind: research · Impact: medium

## In brief

- Ramos, Khan et al. report a conserved developmental state in glioblastoma that is preferentially co-opted in primary and recurrent tumor cells.
- The state resembles late-gestation glial intermediate progenitor cells (gIPCs).
- The authors identify POU3F3 as a factor that sustains this glial progenitor-like state.

## Why it matters

The work links glioblastoma, including recurrent tumors, to a normal developmental cell state and identifies POU3F3 as a candidate that sustains it, which may suggest new therapeutic targets.

## Timeline

- 2026-11-11: Study published online (Glial progenitor-like state is preferentially co-opted in glioblastoma and sustained by POU3F3)

## Coverage

- [Glial progenitor-like state is preferentially co-opted in glioblastoma and sustained by POU3F3](https://www.cell.com/neuron/fulltext/S0896-6273(26)00808-1?rss=yes) — cell.com, 2026-11-11

Tags: glioblastoma, cancer biology, oncofetal, neurodevelopment, pou3f3

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science