# Gene discovery and pleiotropic architecture of multidimensional pain in a genome-wide association study of >1.2 million individuals

Source: [nature.com](https://www.nature.com/articles/s41593-026-02455-1) · 2026-11-12 · Mind
Page: https://themorning.science/story/gene-discovery-and-pleiotropic-architecture-of-multidimensional-pain-in-a-genome-19900d5c633203aa
Kind: research · Impact: medium

## In brief

- A meta-analytic genome-wide association study covered more than 1.2 million European-ancestry individuals.
- The study identified 343 independent loci associated with multidimensional pain.
- The article was published online in Nature Neuroscience on 12 November 2026.

## Why it matters

The large sample and hundreds of loci give pain researchers a broad genetic basis for studying multidimensional pain, which may help explain why pain differs between people.

## Timeline

- 2026-11-12: Study published online in Nature Neuroscience

## Coverage

- [Gene discovery and pleiotropic architecture of multidimensional pain in a genome-wide association study of >1.2 million individuals](https://www.nature.com/articles/s41593-026-02455-1) — nature.com, 2026-11-12

Tags: pain, genetics, gwas, neuroscience, pleiotropy

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science