# Extracellular vesicle-mediated CD47 transfer rewires integrin-IGF1R signaling and tumor immune remodeling to propagate cetuximab resistance

Source: [cell.com](https://www.cell.com/cell-reports/fulltext/S2211-1247(26)01331-8?rss=yes) · 2026-11-11 · Life
Page: https://themorning.science/story/extracellular-vesicle-mediated-cd47-transfer-rewires-integrin-igf1r-signaling-an-896ef665132b6402
Kind: research · Impact: medium

## In brief

- ALIX-dependent sorting of CD47 into extracellular vesicles is reported to propagate cetuximab resistance by promoting integrin-IGF1R signaling.
- Disrupting EV release is reported to remodel the tumor immune microenvironment and restore cetuximab sensitivity.

## Why it matters

The study suggests cetuximab resistance may spread between tumor cells via extracellular vesicles, pointing to EV release as a possible target for overcoming therapy resistance.

## Timeline

- 2026-11-11: Study published in Cell Reports

## Coverage

- [Extracellular vesicle-mediated CD47 transfer rewires integrin-IGF1R signaling and tumor immune remodeling to propagate cetuximab resistance](https://www.cell.com/cell-reports/fulltext/S2211-1247(26)01331-8?rss=yes) — cell.com, 2026-11-11

Tags: extracellular vesicles, cd47, cetuximab, cancer drug resistance, tumor microenvironment

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science