# Enhancer-based AAV approach for selective AADC delivery reduces motor symptoms and dyskinesia in Parkinson’s mouse models

Source: [cell.com](https://www.cell.com/cell-reports/fulltext/S2211-1247(26)01211-8?rss=yes) · 2026-11-12 · Life
Page: https://themorning.science/story/enhancer-based-aav-approach-for-selective-aadc-delivery-reduces-motor-symptoms-a-0cdcd72a55e1ab45
Kind: research · Impact: medium

## In brief

- Chowdhury et al. developed enhancer-driven AAV vectors that achieve cell type-specific AADC expression in mice and non-human primates.
- In Parkinson's disease mouse models, targeting different cell populations produced differing behavioral effects.
- The study reports that the approach reduces motor symptoms and dyskinesia in these models.

## Why it matters

It shows that cell-type-specific gene delivery to the brain can be achieved with enhancer-based AAVs, which could allow more precise AADC gene therapy for Parkinson's and help explain why targeting different cell populations yields different outcomes.

## Timeline

- 2026-11-12: Study published in Cell Reports

## Coverage

- [Enhancer-based AAV approach for selective AADC delivery reduces motor symptoms and dyskinesia in Parkinson’s mouse models](https://www.cell.com/cell-reports/fulltext/S2211-1247(26)01211-8?rss=yes) — cell.com, 2026-11-12

Tags: gene therapy, parkinson's disease, aav, aadc, enhancers, dyskinesia

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science