# Effect of two common GVHD prophylaxis regimens on the gut microbiome in a randomized phase 3 trial

Source: [nature.com](https://www.nature.com/articles/s41591-026-04712-z) · 2026-11-12 · Medicine
Page: https://themorning.science/story/effect-of-two-common-gvhd-prophylaxis-regimens-on-the-gut-microbiome-in-a-random-b623b764d74b29de
Kind: research · Impact: medium

## In brief

- A prespecified companion study (BMT CTN 1801) analysed the gut microbiome within the randomized phase 3 trial BMT CTN 1703, which compared two common GVHD prophylaxis regimens.
- The source excerpt says microbiome diversity at engraftment did not associate with an outcome, but the sentence is cut off, so the full finding is not available here.

## Why it matters

Transplant clinicians choose GVHD prophylaxis regimens partly on their side effects, so evidence on whether these regimens shift the gut microbiome during engraftment is relevant to patient care and microbiome research.

## Versions

- BMT CTN 1703
- BMT CTN 1801

## Timeline

- 2026-11-12: Published online in Nature Medicine

## Coverage

- [Effect of two common GVHD prophylaxis regimens on the gut microbiome in a randomized phase 3 trial](https://www.nature.com/articles/s41591-026-04712-z) — nature.com, 2026-11-12

Tags: gvhd, microbiome, stem cell transplant, clinical trial, immunosuppression

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science