# Dot1 triggers a conserved ribophagy signal to govern ribosome quality and longevity by methylating Rpl12

Source: [cell.com](https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00743-4?rss=yes) · 2026-11-09 · Life
Page: https://themorning.science/story/dot1-triggers-a-conserved-ribophagy-signal-to-govern-ribosome-quality-and-longev-749898936e175b0a
Kind: research · Impact: medium

## In brief

- Chen et al. report that Dot1-mediated methylation of the ribosomal protein Rpl12 acts as an autophagic signal that directs selective ribosome degradation (ribophagy).
- The mechanism links nutrient sensing to ribosome quality control.
- The authors describe the pathway as conserved and linked to cellular stress adaptation, tissue homeostasis and longevity.

## Why it matters

It identifies a specific molecular tag that marks ribosomes for selective autophagic removal, connecting nutrient signalling to ribosome quality and to longevity, which is relevant to aging and stress biology research.

## Timeline

- 2026-11-09: Study published in Molecular Cell

## Coverage

- [Dot1 triggers a conserved ribophagy signal to govern ribosome quality and longevity by methylating Rpl12](https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00743-4?rss=yes) — cell.com, 2026-11-09

Tags: ribophagy, ribosome-quality-control, autophagy, protein-methylation, longevity

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science